People

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PrincipAl InvestigatoR

Sigrid Nachtergaele, PhD

sigrid.nachtergaele@yale.edu

Sigrid (aka Siggy) received her undergraduate degree from the University of Chicago in Biochemistry and Chemistry, while also working in the lab of Rustem Ismagilov and competing on the women’s soccer team. She did her PhD in the Department of Biochemistry at Stanford, working in the lab of Rajat Rohatgi on mechanisms of Hedgehog signaling. Her PhD work developed novel chemical tools to uncover new modes of sterol-mediated regulation of this critical developmental pathway. She headed back to the University of Chicago for a post doc with Chuan He, diving into the world of RNA and working on identifying the functions and regulation of mRNA modifications. When not in the lab, she enjoys sports (playing and spectating), the outdoors (especially the beach!), and playing with Duplo or Play-Doh (usually with her kids).

Postdoctoral fellows

Dr. Muhammad Ramiz Uddin, PhD

muhammadramiz.uddin@yale.edu

Ramiz received his undergraduate degree in Pharmacy from Jahangirnagar University in Dhaka, Bangladesh, followed by a Masters in Pharmaceutical Sciences. He then moved to the University of Oklahoma, where he completed his PhD in Biochemistry under the supervision of Dr. Helen Zgurskaya. His doctoral research focused on dissecting the structural and mechanistic basis of multidrug efflux pumps in Gram-negative bacteria, integrating biochemical, biophysical, and computational approaches to understand pump assembly, conformational regulation, and small-molecule inhibition. Ramiz is now a postdoctoral associate in the Nachtergaele lab, where he is expanding his research into RNA biology and metabolic regulation, building bridges between drug resistance mechanisms and RNA-based pathways. Beyond the lab, he enjoys traveling, exploring new cities, cooking, watching soccer, playing cricket, and spending time outdoors.

Dr. Yi Pan, PhD

y.pan@yale.edu

Graduate students

Dorthy Fang

dorthy.fang@yale.edu

Dorthy Fang received her Bachelor’s degree in Environmental Biology from Columbia University. Prior to starting graduate school, she worked as an assistant scientist at Phanes Therapeutics, Inc. in San Diego. When not in the lab, she enjoys food of all shapes and sizes, jamming to new music, and photosynthesizing outdoors.

Loren Wilson

lauren.wilson@yale.edu

Lauren attended Palomar College before transferring to the University of Arizona, where they graduated with a BS in Molecular and Cellular Biology and Biochemistry. There, they worked in Ross Buchan’s lab studying the regulation of mRNA decay. Now, they are continuing their RNA obsession in the Nachtergaele lab, where they investigate the role of RNA modifications in the assembly of nuclear bodies. When they’re not actively thinking about RNA, Lauren enjoys science fiction, karaoke, and learning to play the accordion.

Clara Wang

clara.wang@yale.edu 

Clara attended Mount Holyoke College where she majored in Biology and minored in Chinese. At Mount Holyoke, she studied bacterial sRNA-protein interactions in Dr. Katie Berry’s lab. After graduating, she worked as a postbaccalaureate research fellow at the NIH in Dr. J. Robert Hogg’s lab studying the mechanisms of nonsense-mediated mRNA decay. Outside of the lab, she enjoys playing tennis, hiking, knitting, and baking! 

Emily Dangelmaier

emily.dangelmaier@yale.edu

Emily graduated from Colgate University with a Bachelor’s degree in Molecular Biology. While completing her undergraduate degree, Emily explored diverse areas of biomedical research in labs at Colgate University, Harvard Medical School, and the NIH. Prior to starting graduate school, she worked as a postbaccalaureate research fellow at the National Cancer Institute at the NIH in the lab of Dr. Ashish Lal, where she studied long noncoding RNAs (lncRNAs) in the context of colorectal cancer, which inspired her interest in RNA biology. When not in the lab, Emily loves going to the beach, doing puzzles, and playing with her dog, Lacy.

Ashton Bollinger

ashton.bollinger@yale.edu

Ashton attended Susquehanna University, where she received a BS in Biochemistry. She conducted undergraduate research in the lab of Dr. Geneive Henry, where she synthesized and characterized a library of novel organic compounds with antioxidant properties. She then worked as a research associate at the Clinic for Special Children in Lancaster, PA, studying rare genetic disesases in Amish and Mennonite populations. Outside the lab, she enjoys watching movies, cross-stitching, and exploring New Haven with her dog!

Isabel Hardy

isabel.hardy@yale.edu

Isabel graduated from Amherst College with a bachelor’s degree in Biochemistry and Biophysics. There, she worked in Ashley Carter’s lab studying the biochemical mechanism underlying the histone-to-protamine transition during sperm cell formation. When not in lab, Isabel loves running, music, and dancing!

Post-graduate researchers

Nicole Harry

nicole.harry@yale.edu 

Nicole completed her undergraduate and graduate studies at the University of New Haven. She received her bachelor’s degree in biology with a minor in music and her master’s degree in Cellular and Molecular Biology. During her graduate studies, Nicole worked in Anna Kloc’s lab to define the epigenetic signatures associated with Epstein-Barr virus infection of the human heart. Nicole is also in the first cohort of the Yale Virtual Internship for Biomedical Education in Science. There she works in the Levy Decision Neuroscience lab researching neural mechanisms underlying decision-making in humans and the possible contribution of decision traits to pathological behavior. Outside of the lab, Nicole enjoys playing the piano, violin, harmonium, and going to the beach!

Renee Pascoe

renee.pascoe@yale.edu

Renee graduated from Lafayette College with a bachelor’s degree in Integrative Engineering with a Bioengineering focus. During her undergraduate studies, she worked in Yih-Choung Yu’s lab on computer simulation of the cardiovascular system and its interactions with left-ventricular assist devices. In her free time, Renee loves crafting, reading, traveling, and trying new restaurants.

Undergraduate researchers
 
 

Ece Serdaroglu

Raj Letchuman
Lab alumni

John Babich, postgraduate researcher, 2023-2025

Zaharaa Altwaij, undergraduate researcher 2024-2025

Yoska Guta, undergraduate researcher 2023-2025

Eddy Tzintzun-Tapia, postgraduate researcher 2022-2024

Kyal Sin Htet, undergraduate researcher 2023-2024 (MCDB Boell Prize winner)

Luke Devereux, graduate student, 2021-2023

Ta’Aliyah Jones, ACS Scholar, summer 2023

Veronica Wall, undergraduate researcher, 2022-2023

Josh Beale, undergraduate researcher 2022-2023 (MCDB Boell Prize winner)

John Tawil, postgraduate researcher 2020-2021

Jessie Gong, undergraduate researcher 2021-2022